ICPEWG Publishes Updated Guidance on Cosmetic Peptide Impurity Reporting

ICPEWG updates guidance on how cosmetic peptide impurities should be reported on COAs.

ICPEWG Publishes Updated Guidance on Cosmetic Peptide Impurity Reporting

2025-04-08

The International Cosmetic Peptide Working Group (ICPEWG) released a revised technical note in Q2 2025 clarifying how suppliers should report related peptides, deletion sequences, and racemization markers on Certificates of Analysis for INCI-listed materials. Importers serving the EU and UK markets are already referencing the document in raw-material qualification questionnaires.

Key takeaway for buyers: impurity thresholds should be negotiated per sequence and per intended use level, not accepted as generic boilerplate. Suppliers unable to provide LC-MS peak assignment for flagged minor components face longer onboarding cycles.